Configuration I: Emulsifying system
Focus on mixing
Can top-quality emulsions consisting of several multi-phase components be produced on a mg, g or kg scale? Flexible oil and aqueous phase may be mixed with each other using the construction shown
below.
Do you wish to work with melts? No problem, because this laboratory plant can also be fitted both with a heating device and with supply lines and pumps. As a result excellent mixtures can be produced which can be easily further processed or analysed.
The micro-reactor system shown on the right has two mixer stage for the production of complex emulsions. It is suited for continuous emulsifying up to +80 °C, whereby melts or soluble materials at a higher temperature can also be processed. For this the base plate is fitted with an electrical base plate heating device. The system may be expanded as desired using additional functional modules of the MMRS.
Frame | MRT-Rack™, anodised aluminium base plate for modules (A4 format) |
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Mixer | Static micro-mixer: 1 x cascade mixer (heatable by liquids) and at the second mixer stage: 1 x LH 2 slit plate mixer, process media connections via the MMRS (1/8", 1/16" Swagelok® or Valco); thermal media connections 1/4‘‘ Swagelok Accessories: Connection adapter for thermostats |
Modules | 4 x inlet/outlet 1/8’‘ Valco, 2 x p sensor modules (100 bar), 2 x Pt100-T sensor (in-line), coaxial heat exchanger and modules with many additional functions available, base plate heating |
Heating/cooling system | Heating/cooling thermostat (e. g. Lauda Proline RP845, Huber Ministat 230) working temperature range -45…+200 °C, heating power 2 kW, cooling power 0.38 kW at 0 °C Accessories: insulated heating hoses, thermal oil |
Dosing system | 2 x SyrDos™ syringe pumps (for low-pressure applications) 2 x GearDos™ micro-tooth ring pumps (for higher pressures and higher flows) Optional: Flow rate controller for micro-tooth ring pumps, heatable micro-tooth ring pumps for the conveying of melt, heatable inlet hoses |
Pressure range | max. 100 bar (dependent on the pump used) |
Sensors | 2 x temperature and pressure sensors: in front of the second mixer stage |
Automation | LabBox® with the following equipment: Interfaces: 8 Pt100 temperature measurement inputs, 8 analogue inputs (current and voltage), 8 analogue outputs (current and voltage), 4 digital outputs (24 V AC), 4 digital outputs (44 V AC), 12 serial interfaces |
Materials | MMRS base plate: Aluminium; parts in contact with media made of stainless steel or Hastelloy (standard, others available on request); seals in contact with media: FFKM otherwise FKM (others available on request) |
Configuration II: Miprowa® Lab system
Focus on exothermic, quick reactions
Never before have you been able to carry out tests so simply and so quickly which in the past were not manageable or hardly controllable using conventional equipment. Using the Miprowa® Lab laboratory reactor, you can measure temperatures at high sampling rates at various parts of the reaction process and also add additional materials to the two liquid reactants to, for example, carry out a quenching process. You would also like to vary the dwell time and other parameters such as pressure to gain a better knowledge of your process? This flexible construction may be put together from modules and the reaction quantities may be adjusted. Miprowa® Lab may be used as an interface module together with micro equipment for process optimisation on a laboratory scale. Following this scale-up is carried out using an analogue channel design, that is to say with the same or similar dimensions of the rectangular flow channels, thus under the same process conditions as in the production scale. Miprowa® apparatus technology is distinguished by a high surface-to-volume ratio of the flow channels, continuous blending of the process flow and its flexibly modifiable apparatus design.
Automated micro-reactor system with flexible regulation and measurement of the reaction temperature. It is suited for continuous synthesis in liquid-liquid (both homogenous and also inhomogenous) and gaseous-liquid reaction mixtures in a temperature range of -20 to +200 °C. The system may be expanded as desired using additional functional modules of the MMRS.
Frame | MRT-Rack™, anodised aluminium base plate for modules (A3 format) |
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Reactor | 1 x Miprowa® Lab reactor with 30 ml interior volume spread across 8 rectangular channels with the dimensions 1.5 x 12 x 300 mm and static mixing elements, integrated temperature measurement (Pt100), process media connections via the MMRS (1/8", 1/16" Swagelok® or Valco), thermal media connections 12 mm Swagelok®, flange for 4/8 channel operation Accessories: Dosing flange for up to 4 additional liquid supply lines or temperature controllers (1/16‘‘ Valco), reducing flanges for 2 or 6 channel operation; connection adapter for thermostats |
Mixer | Static micro-mixer: 1 x comb mixer (other micro-mixers available) |
Modules | 3 x inlet/outlet 1/8’‘ Valco, 2 x p sensor modules (100 bar), 1 x coaxial heat exchanger, many additional modules available |
Heating/cooling system | Heating/cooling thermostat(e. g. Lauda Proline RP845, Huber Ministat 230), working temperature range -45…+200 °C, heating power 2 kW, cooling power 0.38 kW at 0 °C Accessories: insulated heating hoses, thermal oil |
Dosing system | 2 x SyrDos™ syringe pumps (for low-pressure applications) 2 x GearDos™ micro-tooth ring pumps (for higher pressures and higher flows) Optional: Flow rate controller for micro-tooth ring pumps, pumps for additional dosing of further liquid flows, mass flow meter for the dosing of gases |
Pressure range | Max. 30 bar (dependent on the pump used), a pressure regulator may be an advantage when working with gases – obtainable as an MMRS module up to 25 bar working pressure |
Sensors | 2 x temperature sensors: Inlet and outlet of the Miprowa® reactor (optionally up to four additional ones in the dosing flange), 2 x pressure sensors: in front of the mixer |
Automation | LabBox® with the following equipment: Interfaces: 8 Pt100 temperature measurement inputs, 8analogue inputs (current and voltage), 8 analogue outputs (current and voltage), 4 digital outputs (24 V AC), 4 digital outputs (44 V AC), 12 serial interfaces |
Materials | Base plate: Aluminium; parts in contact with media made of stainless steel or Hastelloy (standard, others available on request); seals in contact with media: FFKM otherwise FKM (others available on request) |
Configuration III: System for cryogenic reactions
Focus on complex, multi-stage reactions
A system will be shown in our third example with which demanding safety-related, multi-stage reactions can be carried out in a laboratory at low temperatures (≤-40 °C). Initially, the input materials are brought up to the desired reaction temperature, the mixing then takes place in a temperable micro-mixer and after this there are two dwell reactors which enable a constant mixing of the reaction flow during the reaction. After conclusion of the first reaction stage a sold-content solution is able to be produced with the aid of a special mixer which is then able to continue to react in the third reactor. Such a laboratory set-up provides you with the freedom to efficiently carry out highly demanding reactions under controllable and reproducible conditions. In a very short time you receive various data (p, T, etc.) which enable you to retain an overview of your process and to divide the planning of the scale-up into early, non-critical and phases of the product development and optimisation which are not as yet cost-intensive. Such a compact laboratory plant is of course also suitable for GMP small-volume production.
Automated micro-reactor system with two reaction stages. Suited for continuous synthesis in liquid-liquid (both homogenous and also inhomogenous) and gaseous-liquid reaction mixtures in a temperature range of -45 to +200 °C.
The system is designed for lithiation reactions in which particles could also precipitade in the second stage. Other reactions may be also carried out here, particularly if longer dwell times (of up to 10 minutes) are required. The system may be expanded as desired using additional functional modules of the MMRS.
Frame | MRT-Rack™, anodised aluminium base plate for modules (A3 format) |
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Reactor | 2 x sandwich reactors with 30 ml interior volume and static mixing elements, process media connections via the MMRS, thermal media connections 1/4‘‘ Swagelok® Accessories: fine mixing systems (also reduce the amount of dwell); connection adapter for thermostats 1 x meander reactor (11 ml interior volume, less vulnerable to solid materials due to larger channel size) |
Mixer | Static micro-mixer: Cascade mixer (can be temperature-controlled by liquids) and valve mixer (prevents possible penetration by particles into the front part of system/back-mixing), process media connections via the MMRS (1/8", 1/16" Swagelok® or Valco), thermal media connections 1/4‘‘ Swagelok® Accessories: Connection adapter for thermostats |
Modules | 4 x inlet/outlet 1/8’‘ Valco, 3 x p sensor modules (100 bar), 2 x T sensor modules (Pt100), 2 x coaxial heat exchangers, many additional modules available |
Heating/cooling system | Heating/cooling thermostat(e. g. Lauda Proline RP845, Huber Ministat 230), working temperature range -45…+200 °C, heating power 2 kW, cooling power 0.38 kW at 0 °C Accessories: insulated heating hoses, thermal oil |
Dosing system | 3 x SyrDos™ syringe pumps (for low-pressure applications) 3 x GearDos™ micro-tooth ring pumps (for higher pressures and higher flows) Optional: Flow rate controller for micro-tooth ring pumps, pumps for additional dosing of further liquid flows; mass flow meter for the dosing of gases |
Pressure range | Max. 18 bar (dependent on the pump used) |
Sensors | 2 x temperature sensors: in front of the first mixing step, 3 x pressure sensors: each after the inlet of the 3 reaction elements |
Automation | LabBox® with the following equipment: Interfaces: 8 Pt100 temperature measurement inputs, 8analogue inputs (current and voltage), 8 analogue outputs (current and voltage), 4 digital outputs (24 V AC); 4 digital outputs (44 V AC), 12 serial interfaces |
Materials | Base plate: Aluminium; parts in contact with media made of stainless steel or Hastelloy (standard, others available on request); seals in contact with media: FFKM otherwise FKM (others available on request) |